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KMID : 0123420090140040451
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Korean Journal of Community Nutrition
2009 Volume.14 No. 4 p.451 ~ p.461
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Age-related Circulating Inflammatory Markers and Cardiovascular Disease Risk Factors in Korean Women
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Kwak Ho-Kyung
Kim Mi-Joung
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Abstract
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The purpose of this study was to investigate the age-related changes of cardiovascular disease risk factors and inflammatory markers in non-obese Korean women. Subjects were 112 women over 20 years old with body mass index (BMI) less than 30kg/m2 and were divided into 3 groups (<40 years, 40~59 years, 60 years). Mean weight and BMI in the oldest group were significantly higher than those in the other 2 younger groups (p<0.05). Mean total cholesterol, triglyceride, LDL-cholesterol and apolipoprotein B/apolipoprotein A1 ratio (BAR) in the oldest group were significantly higher than those in the youngest group (p<0.05), and mean HDL-cholesterol of the oldest group was significantly lower than that of the youngest group (p<0.05). The older-aged group showed significantly higher mean values of atherogenic index (AI) and LDL/HDL ratio (p<0.05) than the respective younger-aged group, and AI was significantly correlated with age, nitric oxide and thiobarbituric acid reactive substances (p<0.01). In addition, mean vascular cell adhesion molecule-l (VCAM-1) tended to be higher in the older-aged group than the younger group. Tumor necrosis factor-a, a proinflammatory maker, was significantly positively correlated with serum homocysteine, a cardiovascular disease risk factor (p<0.01). In addition, a significantly positive correlation was observed between C-reactive protein and BAR (p<0.01). Overall results suggested that the aging might affect the increase of cardiovascular disease risk factors including the serum lipid profiles, weight and BMI, and age-related increases of weight and BMI might play a role in changes in certain biomarkers of inflammation.
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KEYWORD
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aging, body mass index, cholesterol, tumor necrosis factor-a, homocysteine
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